Polyomaviruses and Human Neurologic Disease
نویسندگان
چکیده
منابع مشابه
Polyomaviruses and human diseases.
Polyomaviruses are small, nonenveloped DNA viruses, which are widespread in nature. In immunocompetent hosts, the viruses remain latent after primary infection. With few exceptions, illnesses associated with these viruses occur in times of immune compromise, especially in conditions that bring about T cell deficiency. The human polyomaviruses BKV and JCV are known to cause, respectively, hemorr...
متن کاملSeroepidemiology of Human Polyomaviruses
In addition to the previously characterized viruses BK and JC, three new human polyomaviruses (Pys) have been recently identified: KIV, WUV, and Merkel Cell Py (MCV). Using an ELISA employing recombinant VP1 capsid proteins, we have determined the seroprevalence of KIV, WUV, and MCV, along with BKV and JCV, and the monkey viruses SV40 and LPV. Soluble VP1 proteins were used to assess crossreact...
متن کاملSeroepidemiology of the human polyomaviruses.
To assess the stability of polyomavirus antibodies in serial samples over time and the incidence and age-specific prevalence of polyomavirus infections, we established enzyme immunoassays (EIAs) using purified yeast-expressed virus-like particles (VLPs) containing the VP1 major capsid proteins of JC virus (JCV) and the AS and SB strains of BK virus (BKV). A random subsample of 150 Finnish women...
متن کاملAdvances in Human Polyomaviruses Field
Up to 2007, two human polyomaviruses BK (BKPyV) and JC (JCPyV) were known and named after the initials of the patients where they were first isolated. BKV was isolated from the urine of a kidney transplant patient affected by urethral stenosis [1]. JCV was identified in the brain tissue of a patient with Hodgkin lymphoma who developed a demyelinating disease known as progressive multifocal leuk...
متن کاملHuman Polyomaviruses in Skin Diseases
Polyomaviruses are a family of small, nonenveloped viruses with a circular double-stranded DNA genome of ∼5,000 base pairs protected by an icosahedral protein structure. So far, members of this family have been identified in birds and mammals. Until 2006, BK virus (BKV), JC virus (JCV), and simian virus 40 (SV40) were the only polyomaviruses known to circulate in the human population. Their occ...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 1984
ISSN: 0022-3069,1554-6578
DOI: 10.1097/00005072-198401000-00012